CBD Knowledge: Effects, Benefits & the Endocannabinoid System

Cannabidiol is a non-psychoactive active ingredient from the hemp plant that is used in various fields such as medicine, cosmetics, and dietary supplements. In this section CBD knowledge, you will learn everything about its origin, mechanisms of action, legal aspects, and the body's own endocannabinoid system – well-researched, up-to-date, and clearly explained.

What is CBD?

CBD stands for cannabidiol – a natural component of the hemp plant and one of over 100 known cannabinoids. Unlike the psychoactive compound THC, cannabidiol does not cause intoxication. Rather, it is increasingly coming into focus in research, natural medicine, and cosmetics due to its balancing properties. The hemp active ingredient is usually extracted from certified EU industrial hemp, particularly from the leaves and flowers of the plant.

How is CBD produced?

Cannabidiol is produced through a natural chemical process known as decarboxylation – during which cannabidiolic acid (CBDA) is converted into the active cannabidiol. The precursor CBDA originates from cannabigerol (CBG), a "parent molecule" of many cannabinoids. The amount of CBD in a plant depends on genetics, light, climate, and soil quality, among other factors.

Is CBD legal?

Yes – CBD is legal in Germany, Austria, and the EU, provided it comes from EU-certified industrial hemp and the THC content is below 0.3%. It is used in aromatherapy, cosmetics, and medical products, among others. Important: Only products that meet legal requirements are allowed for free trade.

How does CBD work in the body? The endocannabinoid system – briefly explained

The hemp active ingredient cannabidiol supports the so-called endocannabinoid system (ECS) – a central regulatory system in the human body that influences mood, sleep, immune functions, appetite, pain processing, and more. The ECS consists of receptors (CB1 & CB2), endogenous messengers (endocannabinoids), and enzymes. It ensures the balance of many biological processes. CBD acts as an external modulator and can influence the activity of the ECS.

Exogenous cannabinoids from hemp

Cannabidiol belongs to the so-called exogenous cannabinoids, meaning those that are supplied from outside. They can support the function of the body's own systems without being psychoactive – thus contributing to inner balance.

CBD and its receptors: CB1 & CB2

CB1 receptors: These are primarily found in the brain and nervous system. Activated CB1 receptors are involved in:

• Mood and stress regulation
• Pain perception
• Movement coordination
• Neurotransmitters such as serotonin, dopamine, and GABA

CB2 receptors: CB2 receptors are mainly located in the immune system and peripheral tissues. They influence:

• Inflammatory responses
• Immune defense
• Cell protection
• Bone metabolism

What does science say? How does cannabidiol work?

Numerous studies and international research projects deal with the properties of the natural hemp active ingredient. Among other things, the possible role in the following areas is being investigated:

• chronic pain
• inflammatory processes
• irritable bowel syndrome
• inner restlessness or sleep problems

Although many effects are still being researched, promising approaches are emerging to utilize CBD as a complementary component in holistic health concepts.

Anandamide – the "bliss molecule"

Anandamide is an endogenous cannabinoid that supports our well-being, among other things. Cannabidiol can slow down its breakdown, thereby prolonging and enhancing the effect of anandamide. It is involved in:

• Stress processing
• Emotion regulation
• Protection of neuronal structures

What happens in the case of an endocannabinoid deficiency?

A deficient ECS could, according to research, be associated with various complaints – for example:

• concentration disorders
• irritable bowel syndrome
• migraines
• depressive moods

External cannabinoids like CBD could help gently balance imbalances and promote communication within the ECS.

How can the ECS be additionally strengthened?

A healthy lifestyle can support the endocannabinoid system – and thus also the effects of cannabinoids:

• Omega-3 fatty acids (e.g., in hemp oil, fish, flaxseeds)
• Exercise & sports that promote new CB1 receptors
• Probiotic foods that can strengthen the ECS in the gut
• Stress reduction, for example through meditation, sleep, and mindfulness

Conclusion – Why CBD is valuable for health & balance

Cannabidiol is a versatile plant substance with natural potential. Through its effect on the endocannabinoid system, it can contribute to the regulation and balance of numerous bodily functions – in a natural, non-psychoactive way. More and more people are thus using the hemp active ingredient to support:

• regeneration
• inner balance
• a healthy immune system
• a conscious lifestyle.

Sources:
Grotenhermen, F.: Hemp as Medicine. Nachtschatten Verlag, 2017.
Meidinger, W.: Naturally Healing with Cannabis. Kopp Verlag, 2019.
Raab, A.: White Paper Cannabis. Medical Scientific Publishing Company, 2017.
Woodhams S.G. et al, Handb Exp Pharmaco.2015; 227:119-43.doi: 10.1007/978-3-662-46450-2_7.
McPartland, J., PoS One, 2014, 9(3): e89566; doi: 10.1371/journal.pone.0089566.
Russo, E.B., Cannabis Cannabinoid Res, 2016, 1 (1): 154-165; doi: 10.1089/can.2016.0009.
Hasenoehrl, C. et al, Expert Rev Gastroenterol Hepatol, 2017, 11(4): 329-337; doi: 10.1080/17474124.2017.1292851.
Benito, C. et al, Br J Pharmacol., 2008, 153 (2): 277-85.doi: 10.1038/sj.bjp.0707505. Epub 2007 Oct. 15. PMID: 17934510.
Gunduz-Cinar, O. et al, Trends Pharmacol. Sci. 2013 Nov;34 (11): 634-44.doi:10/1016/j.tips.2013.08.008. Epub 2013 Oct. 25. PMID: 24325918.
Marjan, N. et al, Life Science 2016 Feb 1;146:124-30.doi: 10.1016/j.lfs.2015.12.053. Epub 2016 Jan 5.

Typographical errors reserved.